Immunodominance in TCD8+ Responses to Viruses

Plant Resistance Responses to Viruses

Plants have developed numerous approaches to resist infection by viruses. On the other hand, in many instances viruses have evolved to overcome these various resistance responses and barriers. The extent to which viruses can overcome some or all of these responses and barriers determines the extent to which they are able to colonize plants of a given genotype or species. Resistance against plan...

DM peptide-editing function leads to immunodominance in CD4 T cell responses in vivo.

DM functions as a peptide editor for MHC class II-bound peptides. We examined the hypothesis that DM peptide editing plays a key role in focusing the in vivo CD4 T cell responses against complex pathogens and protein Ags to only one, or at most a few, immunodominant peptides. Most CD4 T cells elicited in the wild-type BALB/c (H-2d) mice infected with Leishmania major predominantly recognize a s...

Vivo Immunodominance in CD 4 T Cell Responses DM Peptide - Editing Function Leads to

Immune responses to human papilloma viruses.

HPV infection in the genital tract is common in young sexually active individuals, the majority of whom clear the infection without overt clinical disease. However most of those who develop benign lesions eventually mount an effective cell mediated immune response and the lesions regress. Regression of ano-genital warts is accompanied histologically by a CD4+ T cell dominated Th1 response; anim...

Original antigenic sin responses to influenza viruses.

Most immune responses follow Burnet's rule in that Ag recruits specific lymphocytes from a large repertoire and induces them to proliferate and differentiate into effector cells. However, the phenomenon of "original antigenic sin" stands out as a paradox to Burnet's rule of B cell engagement. Humans, upon infection with a novel influenza strain, produce Abs against older viral strains at the ex...